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Literature summary for 3.1.3.86 extracted from

  • Vandeput, F.; Backers, K.; Villeret, V.; Pesesse, X.; Erneux, C.
    The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity (2006), Cell. Signal., 18, 2193-2199.
    View publication on PubMed
Search for more literature for 3.1.3.86

Activating Compound

Activating Compound Comment Organism Structure
additional information SHIP2 enzyme activity with phosphatidylinositol 3,4,5-trisphosphate is 11fold stimulated in the presence of 0.02 mM vesicles of phosphatidylserine. 0.2 mM vesicles of phosphatidylcholine stimulate 2fold phosphatidylinositol 3,4,5-trisphosphate phosphatase activity of SHIP2 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Homo sapiens in vivo substrate of SHIP2 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-agarose resin column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O in vivo substrate of SHIP2 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O in vitro substrate of SHIP2 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
inositol 1,3,4,5-tetrakisphosphate + H2O in vitro substrate of SHIP2 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
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 Homo sapiens
PtdIns(3,4,5)P3 5-phosphatase
-
 Homo sapiens
SH2 domain containing inositol 5-phosphatase 2
-
 Homo sapiens
SHIP2
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme participates in the insulin signalling pathway in vivo Homo sapiens