Literature summary for 3.1.3.83 extracted from

Wang, L.; Huang, H.; Nguyen, H.H.; Allen, K.N.; Mariano, P.S.; Dunaway-Mariano, D.
Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) (2010), Biochemistry, 49, 1072-1081.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Bacteroides thetaiotaomicron

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.033	-	D-glycero-alpha-D-manno-heptose 1,7-bisphosphate	pH 7.5, 25°C	Bacteroides thetaiotaomicron
0.086	-	D-glycero-beta-D-manno-heptose 1,7-bisphosphate	pH 7.5, 25°C	Bacteroides thetaiotaomicron

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O	Bacteroides thetaiotaomicron	the likely function of the D-glycero-D-mannoheptose 1alpha-GDP pathway of Bacteroides thetaiotaomicron is to generate activated D-glycero-D-manno-heptose units for incorporation into the extracellular capsular polysaccharide	D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Bacteroides thetaiotaomicron	Q8AAI7	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bacteroides thetaiotaomicron

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O	the likely function of the D-glycero-D-mannoheptose 1alpha-GDP pathway of Bacteroides thetaiotaomicron is to generate activated D-glycero-D-manno-heptose units for incorporation into the extracellular capsular polysaccharide	Bacteroides thetaiotaomicron	D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate	-	?
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O	kcat/Km for the alpha-anomer is 6fold higher than for the alpha-anomer	Bacteroides thetaiotaomicron	D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate	-	?
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O	kcat/Km for the alpha-anomer is 6fold higher than for the alpha-anomer	Bacteroides thetaiotaomicron	D-glycero-beta-D-manno-heptose 1-phosphate + phosphate	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
13	-	D-glycero-beta-D-manno-heptose 1,7-bisphosphate	pH 7.5, 25°C	Bacteroides thetaiotaomicron
29	-	D-glycero-alpha-D-manno-heptose 1,7-bisphosphate	pH 7.5, 25°C	Bacteroides thetaiotaomicron

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
151.1	-	D-glycero-beta-D-manno-heptose 1,7-bisphosphate	pH 7.5, 25°C	Bacteroides thetaiotaomicron
879	-	D-glycero-alpha-D-manno-heptose 1,7-bisphosphate	pH 7.5, 25°C	Bacteroides thetaiotaomicron

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Release 2023.1 (January 2023)