Literature summary for 3.1.3.73 extracted from

Warren, M.J.; Raux, E.; Schubert, H.L.; Escalante-Semerena, J.C.
The biosynthesis of adenosylcobalamin (vitamin B12) (2002), Nat. Prod. Rep., 19, 390-412.

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Cloned(Commentary)

Cloned (Comment)	Organism
computer analysis of the cobC and cobD sequences predicts the regulatory regions of these genes to be embedded in the neighbor's coding sequence with only one base pair separating the cobD and cobC coding sequences, the cobC gene is divergently transcribed from the cobD gene	Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
alpha-ribazole-5'-phosphate + H2O	Salmonella enterica	-	alpha -ribazole + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica	-	gene cobC	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
alpha-ribazole-5'-phosphate + H2O	-	Salmonella enterica	alpha -ribazole + phosphate	-	?

General Information

General Information	Comment	Organism
malfunction	the effect of the lack of CobC enzyme on AdoCbl synthesis is most evident when the demand for AdoCbl is high, e.g., during growth on ethanolamine as carbon and energy source. However, when the demand for AdoCbl is low (e.g., synthesis of methionine via the Cbl-dependent methionine synthase), there is no detectable effect on Cbl-dependent growth unless the strain also harbors a null allele of the cobT gene encoding the NaMN:DMB phosphoribosyltransferase enzyme. It is possible that under conditions where low levels of AdoCbl are sufficient to support growth, the activity of a non-specific phosphatase generates alpha-ribazole bypassing the need for CobC activity	Salmonella enterica

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Release 2023.1 (January 2023)