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Literature summary for 3.1.3.67 extracted from

  • Ijuin, T.; Takenawa, T.
    Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP) (2012), J. Biol. Chem., 287, 6991-6999.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
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Mus musculus
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Synonyms

Synonyms Comment Organism
PTEN
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Mus musculus

General Information

General Information Comment Organism
malfunction in PTEN siRNA transfected cells, insulin treatment showed a remarkable increase in PIP3 compared with control cells. PI(3,4)P2 levels are not altered in siRNA-transfected cells. PTEN-knockdown results in an increase in PIP3 levels under basal conditions compared to control cells.Silencing of SKIP, increases the insulin-dependent recruitment of GLUT4 vesicles to the plasma membrane Mus musculus