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Literature summary for 3.1.3.67 extracted from

  • Shearn, C.T.; Smathers, R.L.; Backos, D.S.; Reigan, P.; Orlicky, D.J.; Petersen, D.R.
    Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis (2013), Free Radic. Biol. Med., 65, 680-692.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.67

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxynonenal
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information carbonylation of PTEN increases significantly in ethanol-fed mice compared to pair-fed control animals, corresponding to decreased PTEN3-phosphatase activity Mus musculus
phosphoprotein PTEN expression and PTEN phosphorylation are significantly increased in the livers of ethanol-fed mice Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 carbonylation of PTEN increases significantly in ethanol-fed mice compared to pair-fed control animals, corresponding to decreased PTEN3-phosphatase activity Mus musculus

Synonyms

Synonyms Comment Organism
PTEN
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus PTEN expression and PTEN phosphorylation are significantly increased in the livers of ethanol-fed mice up