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Literature summary for 3.1.3.67 extracted from

  • Vinciguerra, M.; Foti, M.
    PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling (2006), Arch. Physiol. Biochem., 112, 89-104.
    View publication on PubMed
Search for more literature for 3.1.3.67

Application

Application Comment Organism
medicine PTEN plays an important role in insulin-dependent signaling pathways controlling glucose and lipid metabolsim in vivo. A fine tuning of PTEN expression/activation in target organs is likely to be beneficial to correct metabolic dysfunctions in pathological conditions such as insulin resistance diabetes melitus and obesity Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in 3T3L1 adipocytes Mus musculus
overexpressed in MCF-7 breast cancer cell line Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information adipose tissue-specific depletion of PTEN in mice results in improved glucose tolerance and insulin sensitivity rendering mice resistant to streptozotocin-induced diabetes. Increased recruitment of Glut4 transporters at the plasma membrane of adipocytes,whereas the contrary is observed in muscle of the same animals. Decreased expression of resistin is shown Mus musculus
additional information deletion of one PTEN allele in insulin receptor substrate 2 (IRS2) in mice is able to restore pancreatic beta-cell function, peripheral insulin sensitivity, glucose tolerance and significantly increases life span of the animals, indicating that PTEN controls insulin sensitivity in peripheral tissues and pancreatic beta-cell growth and function Mus musculus
additional information liver-specific deletion of PTEN in mice results in enhanced insulin sensitivity, hypoinsulinemia, hypoleptinemia and overall improved glucose tolerance. Adult mice lacking PTEN in liver also develop hepatomegaly syndromes, steatohepatitis and hepatocellular carcinomas Mus musculus
additional information muscle-specific depletion of PTEN in mice results in improved glucose metabolism in animals with diabetes and insulin resistance. Elevated fasting glucose levels are prevented and insulin sensitivity and glucose tolerance in high-fat fed animals are improved. Insulin stimulated Akt-activation is enhanced. PTEN depletion in muscle is not associated with increased tumorigenesis Mus musculus
additional information overexpresion of catalytically inactive or dominant-negative PTEN mutants in 3T1-L1 adipocytes show that it is the lipid phosphatase activity of PTEN which is required to downregulate Akt/PKB signaling and glucose uptake in response to insulin Mus musculus
additional information PTEN downregulation in 3T1-L1 adipocytes by small interfering RNAs enhances Akt/PKB activation and glucose uptake in response to insulin Mus musculus
additional information PTEN null mutations in mice are lethal at embryonic stages and even a 50% reduction in PTEN expression leads to increased tumorigenesis Mus musculus
additional information PTEN overexpression in 3T1-L1 adipocytes causes inhibition of insulin-induced PtdIns(3,4)P2 and PtdIns(3,4,5)P3 production, Akt/PKB activation, GLUT4 translocation to the cell membrane and glucose uptake Mus musculus
additional information PTEN overexpression in MCF-7 breast cancer cell line prevents ERK1/2 phosphorylation in response to insulin. Inhibition of ERK1/2 activation is not only caused by a reduction in PtdIns(3,4,5)P3 level but also by a decreased association of Shc with Grb2/Sos complex and Ras activation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
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 Mus musculus
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breast cancer cell line
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Mus musculus 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate
-
 ?
phosphatidylinositol 3,4-bisphosphate + H2O
-
 Mus musculus phosphatidylinositol 4-phosphate + phosphate
-
 ?
phosphatidylinositol 3,4-bisphosphate + H2O
-
 Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PTEN
-
 Mus musculus
PTEN
-
 Homo sapiens