Literature summary for 3.1.3.67 extracted from

Sun, H.; Lesche, R.; Li, D.M.; Liliental, J.; Zhang, H.; Gao, J.; Gavrilova, N.; Mueller, B.; Liu, X.; Wu, H.
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5-trisphosphate and Akt/protein kinase B signaling pathway (1999), Proc. Natl. Acad. Sci. USA, 96, 6199-6204.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Phosphatidylinositol-3,4,5-trisphosphate + H2O	Mus musculus	PTEN regulates the phosphatidylinositol-3,4,5-trisphosphate and Akt signaling pathway and consequently modulates two critical cellular processes: cell cycle progression and cell survival	Phosphatidyl inositol-4,5-bisphosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	embryonic fibroblast	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Phosphatidylinositol-3,4,5-trisphosphate + H2O	PTEN regulates the phosphatidylinositol-3,4,5-trisphosphate and Akt signaling pathway and consequently modulates two critical cellular processes: cell cycle progression and cell survival	Mus musculus	Phosphatidyl inositol-4,5-bisphosphate + phosphate	-	?

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Release 2023.1 (January 2023)