Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.67 extracted from

  • Georgescu, M.M.; Kirsch, K.H.; Akagi, T.; Shishido, T.; Hanafusa, H.
    The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region (1999), Proc. Natl. Acad. Sci. USA, 96, 10182-10187.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.67

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PTEN is a tumor suppressor inactivated in a variety of cancers such as glioblastoma and endometrial and prostate carcinoma. It acts as a phosphatidylinositol 3,4,5-triphosphate phosphatase antagonizing the activity of the phosphatidylinositol 3-OH kinase. The C-terminal region of PTEN contains secondary structure elements that are essential for the tumor-suppressor function of the protein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PTEN is a tumor suppressor inactivated in a variety of cancers such as glioblastoma and endometrial and prostate carcinoma. It acts as a phosphatidylinositol 3,4,5-triphosphate phosphatase antagonizing the activity of the phosphatidylinositol 3-OH kinase. The C-terminal region of PTEN contains secondary structure elements that are essential for the tumor-suppressor function of the protein Homo sapiens ?
-
 ?