Literature summary for 3.1.3.67 extracted from

Han, S.Y.; Kato, H.; Kato, S.; Suzuki, T.; Shibata, H.; Ishii, S.; Shiiba, K.I.; Matsuno, S.; Kanamaru, R.; Ishioka, C.
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay (2000), Cancer Res., 60, 3147-3151.

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A121P	inactive mutant enzyme	Homo sapiens
C105F	inactive mutant enzyme	Homo sapiens
C124R	inactive mutant enzyme	Homo sapiens
C136Y	inactive mutant enzyme	Homo sapiens
C71Y	inactive mutant enzyme	Homo sapiens
D107Y	inactive mutant enzyme	Homo sapiens
D331G	mutant enzyme with partial activity	Homo sapiens
F342N	mutant enzyme with partial activity	Homo sapiens
F347L	mutant enzyme with partial activity	Homo sapiens
G129E	inactive mutant enzyme	Homo sapiens
G129R	inactive mutant enzyme	Homo sapiens
G165R	inactive mutant enzyme	Homo sapiens
G20E	mutant enzyme with partial activity	Homo sapiens
G251C	inactive mutant enzyme	Homo sapiens
H61R	inactive mutant enzyme	Homo sapiens
H93Y	inactive mutant enzyme	Homo sapiens
K289E	mutant enzyme with partial activity	Homo sapiens
L112P	inactive mutant enzyme	Homo sapiens
L112R	inactive mutant enzyme	Homo sapiens
L345Q	inactive mutant enzyme	Homo sapiens
L42R	activity is comparable with or even higher than that of wild-type enzyme	Homo sapiens
M134L	mutant enzyme with partial activity	Homo sapiens
R130G	inactive mutant enzyme	Homo sapiens
R130L	inactive mutant enzyme	Homo sapiens
R130Q	inactive mutant enzyme	Homo sapiens
R173C	inactive mutant enzyme	Homo sapiens
R173H	inactive mutant enzyme	Homo sapiens
R173P	inactive mutant enzyme	Homo sapiens
S10N	activity is comparable with or even higher than that of wild-type enzyme	Homo sapiens
S170N	inactive mutant enzyme	Homo sapiens
S170R	inactive mutant enzyme	Homo sapiens
S227F	mutant enzyme with partial activity	Homo sapiens
T401I	activity is comparable with or even higher than that of wild-type enzyme	Homo sapiens
V133I	inactive mutant enzyme	Homo sapiens
V343E	inactive mutant enzyme	Homo sapiens
V369G	activity is comparable with or even higher than that of wild-type enzyme	Homo sapiens
Y155C	inactive mutant enzyme	Homo sapiens
Y16C	inactive mutant enzyme	Homo sapiens
Y174N	inactive mutant enzyme	Homo sapiens
Y27S	inactive mutant enzyme	Homo sapiens
Y68H	inactive mutant enzyme	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphatidylinositol-3,4,5-trisphosphate + H2O	Homo sapiens	lipid phosphatase activity of PTEN is critical for its tumor suppressor function and the enzyme negatively regulates the phosphatidylinositol 3'-kinase-protein kinase B pathway	phosphatidylinositol-4,5-bisphosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
inositol 1,3,4,5-tetrakisphosphate + H2O	-	Homo sapiens	inositol 1,4,5-trisphosphate + phosphate	-	?
phosphatidylinositol 3,4,5-trisphosphate + H2O	-	Homo sapiens	phosphatidyl inositol 4,5-bisphosphate + phosphate	-	?
phosphatidylinositol-3,4,5-trisphosphate + H2O	lipid phosphatase activity of PTEN is critical for its tumor suppressor function and the enzyme negatively regulates the phosphatidylinositol 3'-kinase-protein kinase B pathway	Homo sapiens	phosphatidylinositol-4,5-bisphosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PTEN	-	Homo sapiens