Literature summary for 3.1.3.67 extracted from

Zhang, P.; Steinberg, B.M.
Overexpression of PTEN/MMAC1 and decreased activation of Akt in human papillomavirus-infected laryngeal papillomas (2000), Cancer Res., 60, 1457-1462.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphatidylinositol-3,4,5-trisphosphate + H2O	Homo sapiens	PTEN/MMAC is a tumor suppressor that dephosphorylates phosphatidylinositol-3,4,5-trisphosphate, an intermediate in the PI 3-K/Akt signaling pathway	phosphatidylinositol-4,5-bisphosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
papilloma cell	papillomavirus-infected laryngeal papillomas overexpress PTEN/MMAC1	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphatidylinositol-3,4,5-trisphosphate + H2O	-	Homo sapiens	phosphatidylinositol-4,5-bisphosphate + phosphate	-	?
phosphatidylinositol-3,4,5-trisphosphate + H2O	PTEN/MMAC is a tumor suppressor that dephosphorylates phosphatidylinositol-3,4,5-trisphosphate, an intermediate in the PI 3-K/Akt signaling pathway	Homo sapiens	phosphatidylinositol-4,5-bisphosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PTEN/MMAC1	-	Homo sapiens

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Release 2023.1 (January 2023)