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Literature summary for 3.1.3.64 extracted from

  • Mochizuki, Y.; Ohashi, R.; Kawamura, T.; Iwanari, H.; Kodama, T.; Naito, M.; Hamakubo, T.
    Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways (2013), J. Biol. Chem., 288, 1009-1021.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.64

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information deletion of the GRAM domain (amino acids 142-617) abolishes the binding of Rab1B Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
perinuclear space condensed in the perinuclear region in a microtubule-dependent manner. Rab1B regulates the localization of MTMR6 Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
71000
-
 SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus MTMR6 interacts with GDP-bound Rab1B via the GRAM domain ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
heart
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-
spleen
-
 Mus musculus
-
testis contains a spliced isoform Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MTMR6 interacts with GDP-bound Rab1B via the GRAM domain Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MTMR6
-
 Mus musculus

General Information

General Information Comment Organism
malfunction reduction of MTMR6 accelerates the transport of vesicular stomatitis virus glycoprotein in which Rab1B is involved. Furthermore, reduction of MTMR6 or Rab1B inhibits the formation of the tubular omegasome that is induced by overexpression of DFCP1 in autophagy Mus musculus