Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.64 extracted from

  • Taguchi-Atarashi, N.; Hamasaki, M.; Matsunaga, K.; Omori, H.; Ktistakis, N.; Yoshimori, T.; Noda, T.
    Modulation of local Ptdins3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy (2010), Traffic, 11, 468-478.
    View publication on PubMed
Search for more literature for 3.1.3.64

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type myotubularin-related phosphatase in A-549 cells, overexpression of a dominant-negative inactive mutant of myotubularin-related phosphatase 3, that partially localizes to autophagosomes, and PtdIns3P and two autophagy-related PtdIns3P-binding proteins, GFPDFCP1 and GFP-WIPI-1alpha, in A-549 cells, the recombinant enzyme accumulates at sites of autophagosome formation Homo sapiens

Protein Variants

Protein Variants Comment Organism
C413S a dominant-negative inactive mutant of myotubularin-related phosphatase 3. The distribution of MTMR3C413S substantially overlaps with both autophagy-related PtdIns3P-binding proteins GST-2xFYVE and GFP-LC3, demonstrating that the amount of PtdIns3P is focally increased in areas of MTMR3C413S accumulation on autophagosomes Homo sapiens
additional information knockdown of MTMR3 increases autophagosome formation, and overexpression of wild-type MTMR3 led to significantly smaller nascent autophagosomes and a net reduction in autophagic activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Homo sapiens 5768
-
lysosome
-
 Homo sapiens 5764
-
phagosome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PtdIns3P phosphatase binds protein DFCP1, which is associated with autophagosome formation, and DFCP1 localizes to the endoplasmic reticulum and omegasomes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PtdIns3P phosphatase binds protein DFCP1, which is associated with autophagosome formation, and DFCP1 localizes to the endoplasmic reticulum and omegasomes Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MTMR3
-
 Homo sapiens
myotubularin-related phosphatase 3
-
 Homo sapiens
PI 3-phosphatase
-
 Homo sapiens
PI phosphatase
-
 Homo sapiens
PtdIns3P
-
 Homo sapiens
PtdIns3P phosphatase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction inactivation or knockdown of MTMR3 initiates autophagosome formation, and overexpression of wild-type MTMR3 led to significantly smaller nascent autophagosomes and a net reduction in autophagic activity Homo sapiens
metabolism autophagy initiation depends on the balance between PI 3-kinase and PI 3-phosphatase activity Homo sapiens
additional information WIPI-1alpha, a homologue of the yeast autophagy protein Atg18, directly binds PtdIns3P and forms puncta in mammalian cells in a PI 3-kinasedependent manner Homo sapiens
physiological function autophagy initiation depends on the balance between PI 3-kinase and PI 3-phosphatase activity. Effect of MTMR3 on the cellular distribution of PtdIns3P, overview Homo sapiens