Literature summary for 3.1.3.64 extracted from

Zou, J.; Chang, S.C.; Marjanovic, J.; Majerus, P.W.
MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis (2009), J. Biol. Chem., 284, 2064-2071.

Search for more literature for 3.1.3.64

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	myotubularin-related protein 6 is activated up to 28fold in the presence of phosphatidylserine liposomes, myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 and assayed in phosphatidylserine liposomes increases 84fold	Homo sapiens
myotubularin-related protein 9	myotubularin-related protein 9 increases the binding of myotubularin-related protein 6 to phospholipids without changing the lipid binding profile, myotubularin-related protein 9 increases the 3-phosphatase activity of myotubularin-related protein 6 up to 6fold, myotubularin-related protein 9 potentiates the effects of myotubularin-related protein 6 on apoptosis	Homo sapiens
phosphatidylinositol 4-phosphate	phosphatidylinositol 4-phosphate increases myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 in 100% phosphatidylserine	Homo sapiens
phosphatidylinositol 5-phosphate	allosteric activator, phosphatidylinositol 5-phosphate and increases myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 in 100% phosphatidylserine	Homo sapiens
phosphatidylserine	myotubularin-related protein 6 activity increases 1.8fold in both 50% and 100% phosphatidylserine	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf9 insect cells, HEK-293 TRex cells, and in HeLa cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	in the presence of myotubularin-related protein 9 , both phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate have an inhibitory effect on myotubularin-related protein 6 activity in 50% phosphatidylserine, the 3-phosphatase activity decreases 30 and 40% for phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate, respectively	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
115000	-	SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
anti-FLAG affinity column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphatidylinositol 3-phosphate + H2O	-	Homo sapiens	phosphatidylinositol + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
MTM6	-	Homo sapiens
myotubularin-related protein 6	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	-	Homo sapiens

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Release 2023.1 (January 2023)