Cloned (Comment) | Organism |
---|---|
expressed as an N-terminal FLAG-tagged fusion construct | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C375S | a phosphatase-dead mutant of MTM1 also localizes in early and late endosomes | Homo sapiens |
additional information | loss of endosomal phosphatidylinositol 3-phosphate upon overexpression of wild-type MTM1, but not a phosphatase-dead MTM1C375S mutant, results in altered early and late endosomal phosphatidylinositol 3-phosphate levels and rapid depletion of early endosome antigen-1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | MTM1 localizes to both early and late endosomes and associates with the hVPS15/hVPS34 complex. Both Rab7 and MTM1 bind to hVPS15, the hVPS34 adapter molecule that regulates hVPS34 activity through its interactions with Rab5 and Rab7. The WD40 domain of hVPS15 mediates binding to Rab5, Rab7 and MTM1. Consequently, binding of the hVPS15/hVPS34 complex to the Rab GTPases and MTM1 is mutually exclusive | Homo sapiens | 5768 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
MTM1 | - |
Homo sapiens |
myotubular myopathy 1 PI 3-phosphatase | - |
Homo sapiens |
myotubularin | - |
Homo sapiens |