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Literature summary for 3.1.3.64 extracted from

  • Nandurkar, H.H.; Caldwell, K.K.; Whisstock, J.C.; Layton, M.J.; Gaudet, E.A.; Norris, F.A.; Majerus, P.W.; Mitchell, C.A.
    Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity (2001), Proc. Natl. Acad. Sci. USA, 98, 9499-9504.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.64

Cloned(Commentary)

Cloned (Comment) Organism
cDNA encoding the adapter subunit 3-PAP of phosphatidylinositol 3-phosphate 3-phosphatase is cloned, sequenced and characterized, expression of 3-PAP in SF9 insect cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol platelet Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
86000
-
 x * 86000 + x * ?, adapter subunit 3-PAP of phosphatidylinositol 3-phosphate phosphatase, forms a complex with a catalytic subunit of unknown MW, predicted from the amino acid sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9C0I1 adapter subunit 3-PAP of phosphatidylinositol 3-phosphate phosphatase
-

Source Tissue

Source Tissue Comment Organism Textmining
brain adapter subunit 3-PAP mRNA, 2 transcripts of 5.5 and 2.5 kb Homo sapiens
-
heart adapter subunit 3-PAP mRNA, 2 transcripts of 5.5 and 2.5 kb Homo sapiens
-
kidney adapter subunit 3-PAP mRNA, highest abundance in liver, kidney, lung and placenta, 2 transcripts of 5.5 and 2.5 kb Homo sapiens
-
liver adapter subunit 3-PAP mRNA, highest abundance in liver, kidney, lung and placenta, 2 transcripts of 5.5 and 2.5 kb Homo sapiens
-
lung adapter subunit 3-PAP mRNA, highest abundance in liver, kidney, lung and placenta, 2 transcripts of 5.5 and 2.5 kb Homo sapiens
-
placenta adapter subunit 3-PAP mRNA, highest abundance in liver, kidney, lung and placenta, 2 transcripts of 5.5 and 2.5 kb Homo sapiens
-
platelet isolation of adapter subunit 3-PAP immunoprecipitates Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information not: phosphatidylinositol 3,4,5-trisphosphate Homo sapiens ?
-
 ?
additional information the adapter subunit 3-PAP of phosphatidylinositol 3-phosphate phosphatase alone is catalytically inactive Homo sapiens ?
-
 ?
phosphatidylinositol 3,4-bisphosphate + H2O
-
 Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
 ?
phosphatidylinositol 3-phosphate + H2O
-
 Homo sapiens phosphatidylinositol + phosphate
-
 ?

Subunits

Subunits Comment Organism
More x * 86000 + x * ?, adapter subunit 3-PAP of phosphatidylinositol 3-phosphate phosphatase, forms a complex with a catalytic subunit of unknown MW, predicted from the amino acid sequence Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens