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Literature summary for 3.1.3.6 extracted from

  • Freitas-Mesquita, A.L.; Meyer-Fernandes, J.R.
    3'nucleotidase/nuclease in protozoan parasites Molecular and biochemical properties and physiological roles (2017), Exp. Parasitol., 179, 1-6 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 3'-ribonucleotide + H2O Leishmania amazonensis
-
a ribonucleoside + phosphate
-
?
a 3'-ribonucleotide + H2O Crithidia sp.
-
a ribonucleoside + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Crithidia sp.
-
-
-
Leishmania amazonensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-AMP + H2O
-
Leishmania amazonensis adenosine + phosphate
-
?
3'-AMP + H2O
-
Crithidia sp. adenosine + phosphate
-
?
a 3'-ribonucleotide + H2O
-
Leishmania amazonensis a ribonucleoside + phosphate
-
?
a 3'-ribonucleotide + H2O
-
Crithidia sp. a ribonucleoside + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Leishmania amazonensis
? x * 40000, SDS-PAGE Crithidia sp.

Synonyms

Synonyms Comment Organism
3'-nucleotidase/nuclease
-
Leishmania amazonensis
3'-nucleotidase/nuclease
-
Crithidia sp.
3'NT/NU
-
Leishmania amazonensis
3'NT/NU
-
Crithidia sp.

Expression

Organism Comment Expression
Leishmania amazonensis the activity and expression of the enzyme are increased when the parasites are submitted to purine starvation up

General Information

General Information Comment Organism
physiological function the enzyme plays a role in parasite escape from neutrophil extracellular traps, one of the first mechanisms of the host immune system for preventing infection Leishmania amazonensis