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Literature summary for 3.1.3.56 extracted from
- Properties of type II inositol polyphosphate 5-phosphatase (1995), J. Biol. Chem., 270, 9370-9377.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Sf9 insect cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C939S | eliminates isoprenylation of enzyme which reduces activity towards phosphatidylinositol 4,5-bisphosphate | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O | Homo sapiens | - |
phosphatidylinositol 4-phosphate + phosphate | - |
? |  |
| D-myo-inositol 1,4,5-trisphosphate + H2O | Homo sapiens | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| inositol 4,5-bisphosphate + H2O | Homo sapiens | - |
inositol 4-phosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | isoprenylation at Cys-939 | Homo sapiens |
| side-chain modification | isoprenylation | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | phosphatidylinositol 4-phosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Homo sapiens | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | inositol 4-phosphate + phosphate | - |
? | |
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