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Literature summary for 3.1.3.56 extracted from
- The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane (1982), Biochem. J., 203, 169-177.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,3-bisphosphoglycerate | competitive with D-myo-inositol 1,4,5-trisphosphate | Homo sapiens |  |
| EDTA | no activity in presence of 1 mM EDTA | Homo sapiens | |
| Glycerophosphoinositol 4,5-bisphosphate | competitive with D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | |
| Glycerophosphoinositol 4-phosphate | - |
Homo sapiens | |
| Mg2+ | above 12 mM | Homo sapiens | |
| additional information | inositol 1,4-bisphosphate does not inhibit enzyme activity | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
D-myo-inositol 1,4,5-trisphosphate | pH 7.0, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | two isoforms postulated one of which is membrane associated | Homo sapiens | 16020 | - |
| soluble | two isoforms postulated one of which is soluble | Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | no effect | Homo sapiens | |
| Mg2+ | required, maximum activity with 1-5 mM, inhibitory above 12 mM | Homo sapiens | |
| Mn2+ | can partially replace Mg2+, 50% of activity with Mg2+ | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,4,5-trisphosphate + H2O | Homo sapiens | - |
D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | ghosts | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0028 | - |
Vmax, pH 7.0, 37°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Homo sapiens | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| glycerophosphoinositol 4,5-bisphosphate + H2O | at 13% of the rate of inositol 1,4,5-trisphosphate hydrolysis | Homo sapiens | glycerophosphoinositol 4-phosphate + phosphate | - |
? | |
| additional information | glycerophosphoinositol 4-phosphate and inositol 1,4-bisphosphate are not hydrolyzed | Homo sapiens | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.5 | - |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 8.5 | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.35 | - |
2,3-bisphosphoglycerate | - |
Homo sapiens | |
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