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Literature summary for 3.1.3.53 extracted from

  • Shibata, K.; Sakai, H.; Huang, Q.; Kamata, H.; Chiba, Y.; Misawa, M.; Ikebe, R.; Ikebe, M.
    Rac1 regulates myosin II phosphorylation through regulation of myosin light chain phosphatase (2015), J. Cell. Physiol., 230, 1352-1364 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q10728
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General Information

General Information Comment Organism
physiological function Rho family G-proteinRac1 inhibits the activity of myosin light chain phosphatase MLCP through a phosphatase that targets MYPT1 and specific inhibitor CPI-17 rather than through the RhoA-Rho dependent kinase (ROCK) pathway. Rac1 inhibition decreases agonist-induced increase in myosin light chain phosphorylation Rattus norvegicus