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Literature summary for 3.1.3.53 extracted from

  • Sutherland, C.; MacDonald, J.A.; Walsh, M.P.
    Analysis of phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase by Phos-tag SDS-PAGE (2016), Am. J. Physiol. Cell Physiol., 310, C681-C691 .
    View publication on PubMed
Search for more literature for 3.1.3.53

Organism

Organism UniProt Comment Textmining
Gallus gallus Q90623
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Rattus norvegicus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of MYPT1 by Rho-associated coiled-coil kinase ROCK occurs at residues Thr697 and Thr855. cAMP-dependent protein kinase phosphorylates these two sites and the neighboring Ser696 and Ser854. Prior phosphorylation at Thr697 and Thr855 by ROCK precludes phosphorylation at Ser696 and Ser854 by cAMP-dependent protein kinase. Phosphorylation at Thr697 and Thr855 by ROCK exposes two other sites of phosphorylation by cAMP-dependent protein kinase Gallus gallus
phosphoprotein treatment of Triton-skinned rat caudal arterial smooth muscle strips with the membrane-impermeant phosphatase inhibitor microcystin or treatment of intact tissue with the membrane-permeant phosphatase inhibitor calyculin A induces slow, sustained contractions that correlate with phosphorylation of MYPT1 at 7 to more than 10 sites Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
artery
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 Rattus norvegicus
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smooth muscle
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 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
MYPT1
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 Rattus norvegicus
MYPT1
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 Gallus gallus
PPP1R12A
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 Rattus norvegicus
PPP1R12A
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 Gallus gallus

General Information

General Information Comment Organism
physiological function treatment of Triton-skinned rat caudal arterial smooth muscle strips with the membrane-impermeant phosphatase inhibitor microcystin or treatment of intact tissue with the membrane-permeant phosphatase inhibitor calyculin A induces slow, sustained contractions that correlate with phosphorylation of MYPT1 at 7 to more than 10 sites Rattus norvegicus