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Literature summary for 3.1.3.53 extracted from

  • Lu, Y.; Zhang, H.; Gokina, N.I.; Mandala, M.; Sato, O.; Ikebe, M.; Osol, G.; Fisher, S.A.
    Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy (2008), Am. J. Physiol. Cell Physiol., 294, C564-C571.
    View publication on PubMed

Application

Application Comment Organism
medicine MYPT1 is downregulated and switches to the splice variant isoform that codes for the COOH-terminal leucine zipper motif in the hypertension of pregnancy model. These changes in MP expression are prevented by treatment with the antihypertensive medicine hydralazine. Early and effective treatment of hypertension during pregnancy may be able to reverse some of the adverse effects on uterine perfusion and fetal development in this disease Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
tautomycetin type 1 phosphatase inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley, virgin rat, pregnant rat, in pregnant rats with hypertension
-

Source Tissue

Source Tissue Comment Organism Textmining
uterus artery Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00085
-
in virgin rats Rattus norvegicus
0.00102
-
in pregnant rats with hypertension Rattus norvegicus
0.00121
-
in pregnant rats Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myosin light-chain phosphate + H2O
-
Rattus norvegicus myosin light-chain + phosphate
-
?

Subunits

Subunits Comment Organism
More myosin phosphatase is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1 PP1, the myosin phosphatase targeting subunit MYPT1, and M21 Rattus norvegicus

Synonyms

Synonyms Comment Organism
MP
-
Rattus norvegicus
myosin phosphatase
-
Rattus norvegicus
MYPT1
-
Rattus norvegicus