Application | Comment | Organism |
---|---|---|
medicine | MYPT1 is downregulated and switches to the splice variant isoform that codes for the COOH-terminal leucine zipper motif in the hypertension of pregnancy model. These changes in MP expression are prevented by treatment with the antihypertensive medicine hydralazine. Early and effective treatment of hypertension during pregnancy may be able to reverse some of the adverse effects on uterine perfusion and fetal development in this disease | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tautomycetin | type 1 phosphatase inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley, virgin rat, pregnant rat, in pregnant rats with hypertension | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
uterus | artery | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00085 | - |
in virgin rats | Rattus norvegicus |
0.00102 | - |
in pregnant rats with hypertension | Rattus norvegicus |
0.00121 | - |
in pregnant rats | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
myosin light-chain phosphate + H2O | - |
Rattus norvegicus | myosin light-chain + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | myosin phosphatase is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1 PP1, the myosin phosphatase targeting subunit MYPT1, and M21 | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
MP | - |
Rattus norvegicus |
myosin phosphatase | - |
Rattus norvegicus |
MYPT1 | - |
Rattus norvegicus |