Literature summary for 3.1.3.53 extracted from

Payne, M.C.; Zhang, H.Y.; Prosdocimo, T.; Joyce, K.M.; Koga, Y.; Ikebe, M.; Fisher, S.A.
Myosin phosphatase isoform switching in vascular smooth muscle development (2006), J. Mol. Cell. Cardiol., 40, 274-282.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	C-terminal leucine-zipper of MYPT 1 subunit is required for cGMP-mediated activation of enzyme	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	isoforms of enzyme targeting subunit 1, MYPT 1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	portal vein, expression of MYPT 1 subunit increases 2fold between postnatal days 6 and 12 with similar increase in enzyme activity. MYPT 1 switches from leucine-zipper positive to leucine-zipper negative isoforms, concordant with a switch from sensitive to resisitant to cGMP-mediated vascular relaxation	Rattus norvegicus	-

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Release 2023.1 (January 2023)