Literature summary for 3.1.3.53 extracted from

Lubomirov, L.T.; Reimann, K.; Metzler, D.; Hasse, V.; Stehle, R.; Ito, M.; Hartshorne, D.J.; Gagov, H.; Pfitzer, G.; Schubert, R.
Urocortin-induced decrease in Ca2+ sensitivity of contraction in mouse tail arteries is attributable to cAMP-dependent dephosphorylation of MYPT1 and activation of myosin light chain phosphatase (2006), Circ. Res., 98, 1159-1167.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	relaxation of submaximally contracted mouse arteries with urocortin results in a decrease in phosphorylation of myosin light chain S19 by 60% and of enzyme regulatory subunit T696 and T850 by 28 and 52%, resp. Effect of urocortin is blocked by Rp-8-CPT-cAMPS and mimicked by Sp-5,6-DCl-cBIMPS	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	regulatory subunit of enzmye is phopshorylated at T696, contraction of intact mouse arteries induced with noradrenaline is associated with a 2fold increase in phosphorylation, which is reversed in arteries relaxed with urocortin	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	of tail	Mus musculus	-
tail	artery of	Mus musculus	-

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Release 2023.1 (January 2023)