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Literature summary for 3.1.3.53 extracted from

  • Niiro, N.; Koga, Y.; Ikebe, M.
    Agonist-induced changes in the phosphorylation of the myosin-binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle (2003), Biochem. J., 369, 117-128.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.53

Cloned(Commentary)

Cloned (Comment) Organism
myosin-binding subunit of MLCP is cloned and expressed in SF9 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation of the myosin-binding subunit of MLCP at Thr-641 inhibits MLCP activity Oryctolagus cuniculus
phospho-CPI-17 MLCP inhibitor protein, phosphorylation at Thr-38 of CPI-17 results in inhibition of MLCP activity; Rho kinase and protein kinase C phosphorylate CPI-17 at Thr-38, CPI-17 phosphorylation plays a role in MLCP regulation Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Oryctolagus cuniculus involved in the regulation of smooth muscle contraction, regulation of the MLCP activity ?
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 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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 New Zealand White rabbits, MLCP
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Rattus norvegicus
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 myosin-binding subunit of MLCP
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of the myosin-binding subunit of MLCP at the inhibitory site Thr-641 inhibits MLCP activity, but may not play a significant role in a mechanism for MLCP regulation, Rho kinase phosphorylates Thr-799, but not Thr-641 Oryctolagus cuniculus
phosphoprotein myosin-binding subunit of MLCP is phosphorylated at Thr-641 and Thr-799 by Rho kinase to 2 mol phosphate/mol of MBS Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
recombinant myosin-binding subunit of MLCP, expressed in SF9 cells Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle from femoral arteries Oryctolagus cuniculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
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 Rattus norvegicus ?
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 ?
additional information regulation of the MLCP activity Oryctolagus cuniculus ?
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 ?
additional information involved in the regulation of smooth muscle contraction, regulation of the MLCP activity Oryctolagus cuniculus ?
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 ?
myosin light-chain phosphate + H2O
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 Oryctolagus cuniculus myosin light-chain + phosphate
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 ?