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Literature summary for 3.1.3.53 extracted from

  • Richards, C.T.; Ogut, O.; Brozovich, F.V.
    Agonist-induced force enhancement. The role of isoforms and phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase (2002), J. Biol. Chem., 277, 4422-4427.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Gallus gallus involved in force regulation in smooth muscle, the relative expression of splice-in/splice-out myosin-targeting subunit isoforms determines the magnitude of agonist-induced force enhancement/Ca2+ sensitization ?
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Organism

Organism UniProt Comment Textmining
Gallus gallus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein inhibition of enzyme activity by phosphorylation of its myosin-targeting subunit, only in adult gizzard, not in adult aortic smooth muscle, phosphorylation is not required for Ca2+ sensitization of force Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
aorta embryonic and adult, smooth muscle, throughout development, exclusive expression of the splice-in myosin-targeting subunit isoform Gallus gallus
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gizzard smooth muscle embryonic and adult, early during development, expression of the splice-in myosin-targeting subunit isoform, then shift from the splice-in to the splice-out isoform, exclusive expression of the splice-out isoform in adult chicken Gallus gallus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involved in force regulation in smooth muscle, the relative expression of splice-in/splice-out myosin-targeting subunit isoforms determines the magnitude of agonist-induced force enhancement/Ca2+ sensitization Gallus gallus ?
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myosin light-chain phosphate + H2O 20 kDa myosin light chain Gallus gallus myosin light-chain + phosphate
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Subunits

Subunits Comment Organism
More the myosin-targeting subunit MYPT has 2 isoforms produced by alternative splicing that differ by a central insert: 133 kDa splice-in and 130 kDa splice-out isoform, expression of the MYPT isoforms is both developmentally regulated and tissue-specific Gallus gallus