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Literature summary for 3.1.3.53 extracted from

  • Kitazawa, T.; Eto, M.; Woodsome, T.P.; Khalequzzaman, M.
    Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle (2003), J. Physiol., 546, 879-889.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation at Thr-695 of the MLCP regulatory subunit MYPT1 inhibits MLCP activity Oryctolagus cuniculus
phospho-CPI-17 MLCP inhibitor protein, phosphorylation at Thr-38 of CPI-17 results in inhibition of MLCP activity Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myosin light-chain phosphate + H2O Oryctolagus cuniculus plays a critical regulatory role in the Ca2+ sensitivity of myosin phosphorylation and smooth muscle contraction myosin light-chain + phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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 male albino rabbits, MLCP, i.e. protein phosphatase type 1
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at Thr-695 of the MLCP regulatory subunit MYPT1 inhibits MLCP activity, Thr-695 phosphorylation is independent of stimulation of G-proteins, Rho-kinase or protein kinase C, MYPT1 can also be phosphorylated at Thr-850, which is a non-inhibitory Rho-kinase site, Thr-850 phosphorylation is activated by G-proteins Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
portal vein phasic smooth muscle Oryctolagus cuniculus
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smooth muscle phasic portal vein and vas deferens smooth muscles Oryctolagus cuniculus
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vas deferens phasic smooth muscle Oryctolagus cuniculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myosin light-chain phosphate + H2O
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 Oryctolagus cuniculus myosin light-chain + phosphate
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 ?
myosin light-chain phosphate + H2O plays a critical regulatory role in the Ca2+ sensitivity of myosin phosphorylation and smooth muscle contraction Oryctolagus cuniculus myosin light-chain + phosphate
-
 ?