Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP | activation of cytosolic enzyme | Columba livia | |
ATP | activation | Columba livia |
Application | Comment | Organism |
---|---|---|
pharmacology | potential site for pharmacological intervention to protect organs against nucleotide depletion | Columba livia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-nitrophenyl phosphate | - |
Columba livia | |
adenosine 5'-(alpha,beta-methylene)diphosphate | not inhibitory | Columba livia |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.7 | - |
5'-AMP | - |
Columba livia | |
7.7 | - |
5'-IMP | - |
Columba livia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Columba livia | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activation | Columba livia |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
150000 | - |
gel filtration | Columba livia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-IMP + H2O | Columba livia | the enzyme is principally responsible for dephosphorylation of 5'-IMP but may have some role in adenosine formation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Columba livia | - |
pigeon | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Columba livia | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
35.8 | - |
- |
Columba livia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-AMP + H2O | - |
Columba livia | adenosine + phosphate | - |
? | |
5'-CMP + H2O | 61.7% of the activity with 5'-AMP | Columba livia | cytidine + phosphate | - |
? | |
5'-dAMP + H2O | i.e. 2'-deoxyadenosine 5'-phosphate | Columba livia | deoxyadenosine + phosphate | - |
? | |
5'-dAMP + H2O | 66% of the activity with 5'-AMP | Columba livia | deoxyadenosine + phosphate | - |
? | |
5'-dGMP + H2O | i.e. 2'-deoxyguanosine 5'-phosphate | Columba livia | deoxyguanosine + phosphate | - |
? | |
5'-dGMP + H2O | 49.9% of the activity with 5'-AMP | Columba livia | deoxyguanosine + phosphate | - |
? | |
5'-dIMP + H2O | i.e. 2'-deoxyinosine 5'-phosphate | Columba livia | deoxyinosine + phosphate | - |
? | |
5'-dIMP + H2O | 60.9% of the activity with 5'-AMP | Columba livia | deoxyinosine + phosphate | - |
? | |
5'-GMP + H2O | 33.5% of the activity with 5'-AMP | Columba livia | guanosine + phosphate | - |
? | |
5'-IMP + H2O | 33.1% of the activity with 5'-AMP | Columba livia | inosine + phosphate | - |
? | |
5'-IMP + H2O | the enzyme is principally responsible for dephosphorylation of 5'-IMP but may have some role in adenosine formation | Columba livia | ? | - |
? | |
5'-TMP + H2O | 15.2% of the activity with 5'-AMP | Columba livia | thymidine + phosphate | - |
? | |
5'-UMP + H2O | 49.5% of the activity with 5'-AMP | Columba livia | uridine + phosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Columba livia |