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Literature summary for 3.1.3.5 extracted from

  • Garvey, E.P.; Lowen, G.T.; Almond, M.R.
    Nucleotide and nucleoside analogues as inhibitors of cytosolic 5'-nucleotidase I from heart (1998), Biochemistry, 37, 9043-9051.
    View publication on PubMed
Search for more literature for 3.1.3.5

Application

Application Comment Organism
pharmacology inhibitors could be used to diminish nucleotide depletion during ischemia/reperfusion Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
(2R,4S,5R)-1-[5-(2-fluoro-2-phosphonoethyl)tetrahydro-4-hydroxy-2-furyl]thymine
-
 Oryctolagus cuniculus
(2R,4S,5R)-1-[tetrahydro-4-hydroxy-5-(2-phosphonoethyl)-2-furyl]thymine
-
 Oryctolagus cuniculus
(2R,5R)-1-[5-(2-fluoro-2-phosphonoethyl)tetrahydro-2-furyl]thymine
-
 Oryctolagus cuniculus
(2R,5S)-1-[tetrahydro-5-(2-phosphonoethyl)-2-furyl]thymine
-
 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
 5'-TMP cytosolic enzyme c-N-I Oryctolagus cuniculus
0.061
-
 5'-dCMP cytosolic enzyme c-N-I Oryctolagus cuniculus
0.11
-
 5'-CMP cytosolic enzyme c-N-I Oryctolagus cuniculus
0.13
-
 5'-dAMP cytosolic enzyme c-N-I Oryctolagus cuniculus
0.32
-
 5'-GMP cytosolic enzyme c-N-I Oryctolagus cuniculus
1
-
 5'-IMP cytosolic enzyme c-N-I Oryctolagus cuniculus
1.2
-
 5'-AMP cytosolic enzyme c-N-I Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Oryctolagus cuniculus 5829
-

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
10
-
 enzyme e-N Oryctolagus cuniculus
71
-
 enzyme c-N-I Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Oryctolagus cuniculus adenosine + phosphate
-
 ?
5'-CMP + H2O
-
 Oryctolagus cuniculus cytidine + phosphate
-
 ?
5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Oryctolagus cuniculus deoxyadenosine + phosphate
-
 ?
5'-dCMP + H2O i.e. 2'-deoxycytosine 5'-phosphate Oryctolagus cuniculus deoxycytidine + phosphate
-
 ?
5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Oryctolagus cuniculus deoxyguanosine + phosphate
-
 ?
5'-GMP + H2O
-
 Oryctolagus cuniculus guanosine + phosphate
-
 ?
5'-IMP + H2O
-
 Oryctolagus cuniculus inosine + phosphate
-
 ?
5'-TMP + H2O
-
 Oryctolagus cuniculus thymidine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
c-N-II
-
 Oryctolagus cuniculus
cN-I
-
 Oryctolagus cuniculus
e-N
-
 Oryctolagus cuniculus