Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine 5'-(alpha,beta-methylene)diphosphate | treatment with 0.001 mM adenosine 5'-(alpha,beta-methylene)diphosphate, a competitive ecto-5'-NT/CD73 inhibitor, causes a significant reduction of 30% in glioma cell proliferation, the inhibitory effect on cell proliferation caused by adenosine 5'-(alpha,beta-methylene)diphosphate is reverted by cotreatment with nitrobenzylthioinosine and dipyridamole | Homo sapiens | |
adenosine 5'-(alpha,beta-methylene)diphosphate | treatment with 0.001 mM adenosine 5'-(alpha,beta-methylene)diphosphate, a competitive ecto-5'-NT/CD73 inhibitor, causes a significant reduction of 30% in glioma cell proliferation, the inhibitory effect on cell proliferation caused by adenosine 5'-(alpha,beta-methylene)diphosphate is reverted by cotreatment with nitrobenzylthioinosine and dipyridamole | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | the enzyme is anchored on the outer surface of the plasma membrane via a glycosyl phosphatidylinositol linkage | Homo sapiens | 5886 | - |
plasma membrane | the enzyme is anchored on the outer surface of the plasma membrane via a glycosyl phosphatidylinositol linkage | Rattus norvegicus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
glycoprotein | - |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C6 glioma cell | - |
Rattus norvegicus | - |
glioma cell | - |
Homo sapiens | - |
glioma cell | - |
Rattus norvegicus | - |
U-138MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-AMP + H2O | - |
Homo sapiens | adenosine + phosphate | - |
? | |
5'-AMP + H2O | - |
Rattus norvegicus | adenosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD73 | - |
Homo sapiens |
CD73 | - |
Rattus norvegicus |
ecto-5'-NT | - |
Homo sapiens |
ecto-5'-NT | - |
Rattus norvegicus |
ecto-5'-NT/CD73 | - |
Homo sapiens |
ecto-5'-NT/CD73 | - |
Rattus norvegicus |
ecto-5'-nucleotidase | - |
Homo sapiens |
ecto-5'-nucleotidase | - |
Rattus norvegicus |