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Literature summary for 3.1.3.5 extracted from

  • Bavaresco, L.; Bernardi, A.; Braganhol, E.; Cappellari, A.R.; Rockenbach, L.; Farias, P.F.; Wink, M.R.; Delgado-Canedo, A.; Battastini, A.M.
    The role of ecto-5'-nucleotidase/CD73 in glioma cell line proliferation (2008), Mol. Cell. Biochem., 319, 61-68.
    View publication on PubMed
Search for more literature for 3.1.3.5

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-(alpha,beta-methylene)diphosphate treatment with 0.001 mM adenosine 5'-(alpha,beta-methylene)diphosphate, a competitive ecto-5'-NT/CD73 inhibitor, causes a significant reduction of 30% in glioma cell proliferation, the inhibitory effect on cell proliferation caused by adenosine 5'-(alpha,beta-methylene)diphosphate is reverted by cotreatment with nitrobenzylthioinosine and dipyridamole Homo sapiens
adenosine 5'-(alpha,beta-methylene)diphosphate treatment with 0.001 mM adenosine 5'-(alpha,beta-methylene)diphosphate, a competitive ecto-5'-NT/CD73 inhibitor, causes a significant reduction of 30% in glioma cell proliferation, the inhibitory effect on cell proliferation caused by adenosine 5'-(alpha,beta-methylene)diphosphate is reverted by cotreatment with nitrobenzylthioinosine and dipyridamole Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane the enzyme is anchored on the outer surface of the plasma membrane via a glycosyl phosphatidylinositol linkage Homo sapiens 5886
-
plasma membrane the enzyme is anchored on the outer surface of the plasma membrane via a glycosyl phosphatidylinositol linkage Rattus norvegicus 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens
glycoprotein
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
C6 glioma cell
-
 Rattus norvegicus
-
glioma cell
-
 Homo sapiens
-
glioma cell
-
 Rattus norvegicus
-
U-138MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?
5'-AMP + H2O
-
 Rattus norvegicus adenosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CD73
-
 Homo sapiens
CD73
-
 Rattus norvegicus
ecto-5'-NT
-
 Homo sapiens
ecto-5'-NT
-
 Rattus norvegicus
ecto-5'-NT/CD73
-
 Homo sapiens
ecto-5'-NT/CD73
-
 Rattus norvegicus
ecto-5'-nucleotidase
-
 Homo sapiens
ecto-5'-nucleotidase
-
 Rattus norvegicus