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Literature summary for 3.1.3.5 extracted from

  • Hart, M.L.; Koehler, D.; Eckle, T.; Kloor, D.; Stahl, G.L.; Eltzschig, H.K.
    Direct treatment of mouse or human blood with soluble 5'-nucleotidase inhibits platelet aggregation (2008), Arterioscler. Thromb. Vasc. Biol., 28, 1477-1483.
    View publication on PubMed
Search for more literature for 3.1.3.5

Application

Application Comment Organism
medicine mouse and human platelet aggregation is completely inhibited after treatment with Crotalus atrox 5'-nucleotidase (5 units/ml) via generation of increased levels of extracellular adenosine and subsequent adenosine receptor signaling Crotalus atrox

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-(alpha,beta-methylene)diphosphate specific inhibitor, complete inhibition at 0.5 mM Crotalus atrox

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Crotalus atrox
-
-

Organism

Organism UniProt Comment Textmining
Crotalus atrox
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Crotalus atrox
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Crotalus atrox adenosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
5'-NT
-
 Crotalus atrox
CD73
-
 Crotalus atrox
ecto-5'-NT
-
 Crotalus atrox
ecto-5'-nucleotidase
-
 Crotalus atrox