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Literature summary for 3.1.3.5 extracted from

  • Garcia-Ayllon, M.S.; Campoy, F.J.; Vidal, C.J.; Munoz-Delgado, E.
    Identification of inactive ecto-5'-nucleotidase in normal mouse muscle and its increased activity in dystrophic Lama2dy mice (2001), J. Neurosci. Res., 66, 656-665.
    View publication on PubMed
Search for more literature for 3.1.3.5

Inhibitors

Inhibitors Comment Organism Structure
ADP competitive Mus musculus
Ap[CH2]p mixed competitive inhibitor Mus musculus
ATP competitive Mus musculus
concanavalin A partial non-competitive Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0119
-
 5'-AMP pH 7.4, 37°C, enzyme from dystrophic muscle Mus musculus
0.0121
-
 5'-AMP pH 7.4, 37°C, enzyme from normal muscle Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
muscle activity in dystrophic muscle is 3 to 4fold that in normal muscle. The higher activity may result from misregulation in the synthesis of active and inactive ecto-5'-nucleotidase species or from conversion of inactive into active components Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Mus musculus adenosine + phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer the active and the inactive enzyme species occur as amphiphilic dimers Mus musculus

Synonyms

Synonyms Comment Organism
ecto-5'-nucleotidase
-
 Mus musculus
eNT
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000022
-
 concanavalin A pH 7.4, 37°C, enzyme from normal muscle Mus musculus
0.000035
-
 Con A pH 7.4, 37°C, enzyme from dystrophic muscle Mus musculus
0.00036
-
 Ap[CH2]p pH 7.4, 37°C, enzyme from normal muscle Mus musculus
0.00045
-
 Ap[CH2]p pH 7.4, 37°C, enzyme from dystrophic muscle Mus musculus
0.0075
-
 ADP pH 7.4, 37°C, enzyme from normal muscle Mus musculus
0.0098
-
 ADP pH 7.4, 37°C, enzyme from dystrophic muscle Mus musculus
0.0138
-
 ATP pH 7.4, 37°C, enzyme from dystrophic muscle Mus musculus
0.0155
-
 ATP pH 7.4, 37°C, enzyme from normal muscle Mus musculus