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Literature summary for 3.1.3.48 extracted from
- Reactive nitrogen species and hydrogen sulfide as regulators of protein tyrosine phosphatase activity (2014), Antioxid. Redox Signal., 20, 2191-2209.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C11A | inactive | Mycobacterium tuberculosis |
| C16A | the mutant retains the activity similar to the wild type enzyme | Mycobacterium tuberculosis |
| C53A | the mutant is insensitive to S-nitrosoglutathione treatment | Mycobacterium tuberculosis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| S-nitrosoglutathione | S-nitrosoglutathione treatment decreases the catalytic activity parameters of PtpA by half | Mycobacterium tuberculosis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [a protein]-tyrosine phosphate + H2O | Mycobacterium tuberculosis | - |
[a protein]-tyrosine + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| S-nitrosylation | - |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [a protein]-tyrosine phosphate + H2O | - |
Mycobacterium tuberculosis | [a protein]-tyrosine + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LMW-PTP | - |
Mycobacterium tuberculosis |
| protein tyrosine phosphatase | - |
Mycobacterium tuberculosis |
| PtpA | - |
Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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