Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of the WPD-loop can be used to potently and specifically turn on the activity of a biologically important tyrosine phosphatase, PTP-PEST | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the catalytically critical loop of the PTP domain, the WPD loop, can be engineered to contain cysteine-rich elements that bind the inhibitory biarsenical reagent | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | improperly regulated PTP activity has been implicated in a range of human diseases including leukemia, solid-tumor cancers, diabetes, and several autoimmune disorders | Homo sapiens |
physiological function | protein tyrosine phosphatases are a large and important class of signaling enzymes that catalyze the dephosphorylation of phosphotyrosine in protein substrates. A number of PTPs are tumor-suppressor proteins. PEST is a wide-ranging and ubiquitously expressed signaling molecule, which is involved in the regulation of osteoclast activation, cell motility and adhesion, the immune response, and apoptosis | Homo sapiens |