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Literature summary for 3.1.3.48 extracted from

  • Ahn, K.S.; Sethi, G.; Sung, B.; Goel, A.; Ralhan, R.; Aggarwal, B.B.
    Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1 (2008), Cancer Res., 68, 4406-4415.
    View publication on PubMed
Search for more literature for 3.1.3.48

Protein Variants

Protein Variants Comment Organism
additional information knockdown of SHP-1 by small interfering RNA suppresses the effect of guggulsterone on induction of SHP-1 and on the inhibition of STAT3 activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
vanadate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information SHP-1 is a nontransmembrane protein tyrosine phosphatase expressed in most cells Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphotyrosyl-STAT3 + H2O Homo sapiens signal transducers and activator of transcription 3, STAT3, is a transcription factor that is associated with survival, proliferation, chemoresistance, and angiogenesis of tumor cells STAT3 + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
MM1-S cell a melphalan-sensitive myeloma cell line, from the peripheral blood cells of a patient with IgA myeloma, secretes lambda L chain, is negative for the presence of the EBV genome, and expresses leukocyte antigen DR, plasma cell Ag-1, and T9 and T10 antigens Homo sapiens
-
additional information SHP-1 is a nontransmembrane protein tyrosine phosphatase expressed in most cells Homo sapiens
-
myeloma cell
-
 Homo sapiens
-
SCC-4 cell a head and neck squamous cell carcinoma cell line Homo sapiens
-
U-266 cell a plasmacytoma of B-cell origin producing monoclonal antibodies and interleukin-6 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphotyrosyl-STAT3 + H2O
-
 Homo sapiens STAT3 + phosphate
-
 ?
phosphotyrosyl-STAT3 + H2O signal transducers and activator of transcription 3, STAT3, is a transcription factor that is associated with survival, proliferation, chemoresistance, and angiogenesis of tumor cells Homo sapiens STAT3 + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase SHP-1
-
 Homo sapiens
PTPase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens guggulsterone, a farnesoid X receptor antagonist, induces the expression of both the protein and mRNA for tyrosine protein phosphatase SHP-1, which is not due to demethylation of the SHP-1 promoter previously implicated in the epigenetic silencing of SHP-1. Induction of SHP-1 leads to inhibition of activation of protein tyrosine kinases Janus-activated kinase 2 and c-Src, and of subsequent activation of STAT3, overview up

General Information

General Information Comment Organism
physiological function SHP-1 is important in the negative regulation of JAK/STAT signaling and is often silenced by methylation in leukemias and lymphomas Homo sapiens