Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-1-(2'-hydroxyphenyl)-3-(1-naphthyl)-2-propen-1-one | 76% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(2,4-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one | 20% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(2,4-dimethoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one | - |
Mycobacterium tuberculosis | |
(2E)-1-(2,5-dimethoxyphenyl)-3-(2-naphthyl)-2-propen-1-one | 58% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(2,5-dimethoxyphenyl)-3-(naphth-1-yl)-2-propen-1-one | 46% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(3-nitrophenyl)prop-2-en-1-one | 8% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one | 16% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(2-hydroxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one | 26% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(3,4-dimethoxyphenyl)-3-(2-naphthyl)-2-propen-1-one | - |
Mycobacterium tuberculosis | |
(2E)-1-(3,4-dimethoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one | 68.5% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(3-hydroxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one | 20% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(3-methoxy-4-hydroxyphenyl)-3-(2-naphthyl)-2-propen-1-one | - |
Mycobacterium tuberculosis | |
(2E)-1-(3-methoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one | 18.5% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(4-bromophenyl)-3-(naphthalen-1-yl)prop-2-en-1-one | 25% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(4-bromophenyl)-3-(naphthalen-2-yl)prop-2-en-1-one | 11% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(4-hydroxy-3-methoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one | 39% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-1-(4-methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one | 18% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one | 8% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(2,5-dimethoxyphenyl)prop-2-en-1-one | 9% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one | - |
Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one | 18% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one | - |
Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(3-nitrophenyl)prop-2-en-1-one | 26% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(4-bromophenyl)prop-2-en-1-one | 14% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one | 20% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)prop-2-en-1-one | 6% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-(4-nitrophenyl)prop-2-en-1-one | 19.5% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(1,3-benzodioxol-5-yl)-1-phenylprop-2-en-1-one | - |
Mycobacterium tuberculosis | |
(2E)-3-(3,4-dichlorophenyl)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-one | - |
Mycobacterium tuberculosis | |
(2E)-3-(3-chlorophenyl)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-one | - |
Mycobacterium tuberculosis | |
(2E)-3-(3-chlorophenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one | 13% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(3-nitrophenyl)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-one | - |
Mycobacterium tuberculosis | |
(2E)-3-(naphthalen-1-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one | - |
Mycobacterium tuberculosis | |
(2E)-3-(naphthalen-1-yl)-1-(3-nitrophenyl)prop-2-en-1-one | 12% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(naphthalen-1-yl)-1-(4-nitrophenyl)prop-2-en-1-one | 18% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one | 37% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(naphthalen-2-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one | 9% activation at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(naphthalen-2-yl)-1-(3-nitrophenyl)prop-2-en-1-one | 16% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(naphthalen-2-yl)-1-(4-nitrophenyl)prop-2-en-1-one | 11% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
(2E)-3-(naphthalen-2-yl)-1-phenylprop-2-en-1-one | 12% inhibition at 0.025 mM | Mycobacterium tuberculosis | |
additional information | synthesis and inhibitory activity of 38 synthetic chalcones towards PtpA, the predominant factor for the activity is the molecule planarity/hydrophobicity and the nature of the substituents, structure-activity analysis, overview. No inhibition by 3a, 3b, 3c, 4h, 5l, 6d, 6g, and 6j | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Mycobacterium tuberculosis | 4-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Mycobacterium tuberculosis |
PtpA | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0084 | - |
pH 8.0, 37°C | Mycobacterium tuberculosis | (2E)-1-(2,5-dimethoxyphenyl)-3-(2-naphthyl)-2-propen-1-one | |
0.0231 | - |
pH 8.0, 37°C | Mycobacterium tuberculosis | (2E)-1-(3,4-dimethoxyphenyl)-3-(2-naphthyl)-2-propen-1-one | |
0.0395 | - |
pH 8.0, 37°C | Mycobacterium tuberculosis | (2E)-1-(2,5-dimethoxyphenyl)-3-(naphth-1-yl)-2-propen-1-one | |
0.0502 | - |
pH 8.0, 37°C | Mycobacterium tuberculosis | (2E)-1-(2'-hydroxyphenyl)-3-(1-naphthyl)-2-propen-1-one | |
0.0537 | - |
pH 8.0, 37°C | Mycobacterium tuberculosis | (2E)-1-(3-methoxy-4-hydroxyphenyl)-3-(2-naphthyl)-2-propen-1-one |