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Literature summary for 3.1.3.48 extracted from

  • Chabot, C.; Spring, K.; Gratton, J.P.; Elchebly, M.; Royal, I.
    New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival (2009), Mol. Cell. Biol., 29, 241-253.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens functional inactivation of the protein tyrosine phosphatase DEP-1 leads to increased endothelial cell proliferation and failure of vessels to remodel and branch ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information functional inactivation of the protein tyrosine phosphatase DEP-1 leads to increased endothelial cell proliferation and failure of vessels to remodel and branch Homo sapiens ?
-
 ?
additional information DEP-1 is a positive regulator of VEGF-mediated Src and Akt activation and endothelial cell survival Homo sapiens ?
-
 ?
phosphorylated Src + H2O DEP-1 is able to dephosphorylate the inhibitory Y529 and activate Src Homo sapiens Src + phosphate
-
 ?
phosphorylated vascular endothelial growth factor receptor 2 + H2O
-
 Homo sapiens vascular endothelial growth factor receptor 2 + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CD148
-
 Homo sapiens
DEP-1
-
 Homo sapiens
protein tyrosine phosphatase
-
 Homo sapiens
PTP-eta
-
 Homo sapiens
PTPRJ
-
 Homo sapiens