Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C473D | active site mutant, weak substrate affinity and dissociates rapidly | Homo sapiens |
C473S | strong substrate affinity and dissociates slowly | Homo sapiens |
R492L | hotspot mutant, dramatically decreased activity despite showing no significant changes in crystal structure | Homo sapiens |
Y497A | shows a significantly slower rate constant for association compared to that of the wild type enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P30305 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated Cdk2-pTpY/CycA protein + H2O | - |
Homo sapiens | Cdk2-pTpY/CycA protein + phosphate | - |
? | |
phosphotyrosine + H2O | - |
Homo sapiens | tyrosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdc25B phosphatase | - |
Homo sapiens |
dual-specificity phosphatase | - |
Homo sapiens |