Crystallization (Comment) | Organism |
---|---|
PTP1B and PTP1B mutant F182H in complex with inhibitors | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F182H | isoform PTP1B, exchange of residue 182 with that of isoform PTPH1, modulation of functionality of catalytic center | Homo sapiens |
H182F | isoform PTP1B, exchange of residue 182 with that of isoform PTPB1, modulation of functionality of catalytic center | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid | - |
Homo sapiens | |
2-(oxalyl-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid | - |
Homo sapiens | |
3-[oxalyl-amino]naphthalene-2-carboxylic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.1 | - |
acetyl-DADEpYL-NH2 | pH 7.0, 30°C, isoform PTPH1 | Homo sapiens | |
1.84 | - |
acetyl-DADEpYL-NH2 | pH 7.0, 30°C, isoform PTP1B, mutant F182H | Homo sapiens | |
4.04 | - |
acetyl-DADEpYL-NH2 | pH 7.0, 30°C, isoform PTP1B | Homo sapiens | |
97.5 | - |
acetyl-DADEpYL-NH2 | pH 7.0, 30°C, isoform PTPH1, mutant H182F | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P18031 | isoforms PTPB1, PTPH1 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate | mechanism, role of residue 182 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-DADEpYL-NH2 + H2O | - |
Homo sapiens | acetyl-DADEYL-NH2 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PTPB1 | - |
Homo sapiens |
PTPH1 | - |
Homo sapiens |