Any feedback?
Literature summary for 3.1.3.47 extracted from
- Partial purification from rat liver microsomes of three native protein phosphatases with activity towards HMG-CoA reductase (1984), J. Lipid Res., 25, 497-506.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diphosphate | - |
Rattus norvegicus |  |
| ethanol | - |
Rattus norvegicus | |
| fluoride | - |
Rattus norvegicus | |
| phosphate | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
microsomal isoenzyme IM, gel chromatography | Rattus norvegicus |
| 90000 | - |
microsomal isoenzyme Ex, gel chromatography | Rattus norvegicus |
| 180000 | - |
microsomal isoenzyme IIM, gel chromatography | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| liver | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 575 | - |
purification 55fold, for microsomal isoenzyme IM | Rattus norvegicus |
| 1030 | - |
purification 98fold, for microsomal isoenzyme IIM | Rattus norvegicus |
| 1375 | - |
purification 130fold, for microsomal isoenzyme Ex | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -40°C, several months, no measurable loss of activity | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate | - |
? | |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
for microsomal isoenzymes IM and IIM, with [hydroxymethylglutaryl-CoA reductase]-phosphate as substrate | Rattus norvegicus |
| 6.5 | - |
for microsomal isoenzyme Ex, with [hydroxymethylglutaryl-CoA reductase]-phosphate as substrate | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
