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Literature summary for 3.1.3.44 extracted from
- Further evidence for the regulation of acetyl-CoA carboxylase activity by a glutamate- and magnesium-activated protein phosphatase in the pancreatic beta cell: defective regulation in the diabetic GK rat islet (2005), Endocrine, 26, 71-77.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activation of carboxymethylation of 36 kDa subunit of enzyme | Rattus norvegicus |  |
| additional information | not activating carboxymethylation: glutamate | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in pancreatic islets derived from diabetic rats, marked reduction of magnesium- and glutamate-sensitive enzyme activity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| okadaic acid | inhibitis carboxymethylation of 36 kDa subunit of enzyme | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | pancreatic beta-cell, normal islets and islets derived from the diabetic Goto-Kakizaki rat | Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAPP | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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