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Literature summary for 3.1.3.43 extracted from
- Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase (1974), Biochem. J., 140, 225-237.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| A23187 | - |
Rattus norvegicus |  |
| Ni2+ | - |
Rattus norvegicus | |
| ruthenium red | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
[Pyruvate dehydrogenase (lipoamide)]-phosphate | with Ca2+ and Mg2+ | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Sus scrofa | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Sus scrofa | |
| Ca2+ | Km: 0.001 | Rattus norvegicus | |
| Mg2+ | - |
Sus scrofa | |
| Mg2+ | Km: 0.52 mM | Rattus norvegicus | |
| Sr2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | Rattus norvegicus | - |
? | - |
? | |
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | Sus scrofa | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose | - |
Rattus norvegicus | - |
| epididymis | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| heart | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Rattus norvegicus | [pyruvate dehydrogenase (lipoamide)] + phosphate | - |
ir | |
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Sus scrofa | [pyruvate dehydrogenase (lipoamide)] + phosphate | - |
ir | |
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Rattus norvegicus | ? | - |
? | |
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Sus scrofa | ? | - |
? | |
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Release 2023.1 (January 2023)
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