Literature summary for 3.1.3.43 extracted from

Chen, J.; Guccini, I.; Mitri, D.; Brina, D.; Revandkar, A.; Sarti, M.; Pasquini, E.; Alajati, A.; Pinton, S.; Losa, M.; Civenni, G.; Catapano, C.; Sgrignani, J.; Cavalli, A.; DAntuono, R.; Asara, J.; Morandi, A.; Chiarugi, P.; Crotti, S.; Agostini, M.
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer (2018), Nat. Genet., 50, 219-228 .

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Application

Application	Comment	Organism
medicine	pyruvate dehydrogenase subunit PDHA1 and pyruvate dehydrogenase phosphatase PDP1 are frequently amplified and overexpressed at both the gene and protein levels in prostate tumors	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
prostate gland	-	Homo sapiens	-
prostate gland cancer cell	pyruvate dehydrogenase subunit PDHA1 and pyruvate dehydrogenase phosphatase PDP1 are frequently amplified and overexpressed at both the gene and protein levels in prostate tumors	Homo sapiens	-

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Release 2023.1 (January 2023)