Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | in embryonic stem cells, Pdp1 expression is 27fold decreased on differentiation day 8 compared to differentiation day 0, accompanied by suppressed mitochondrial indices, including ATP levels, membrane potential, reactive oxygen species and mitochondrial Ca2+. Pdp1 overexpression significantly enhances the mitochondrial indices and pyruvate dehydrogenase activity and reduces the expression of cardiac differentiation marker mRNA and the cardiac differentiation rate. A knockdown of the Pdp1 gene promotes the expression of cardiac differentiation marker mRNA and the cardiac differentiation rate | Mus musculus |