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Literature summary for 3.1.3.43 extracted from

  • Heo, H.; Kim, H.; Youm, J.; Cho, S.; Song, I.; Lee, S.; Ko, T.; Kim, N.; Ko, K.; Rhee, B.; Han, J.
    Mitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells (2016), Exp. Mol. Med., 48, e254 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Mus musculus 5739
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
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Mus musculus
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General Information

General Information Comment Organism
physiological function in embryonic stem cells, Pdp1 expression is 27fold decreased on differentiation day 8 compared to differentiation day 0, accompanied by suppressed mitochondrial indices, including ATP levels, membrane potential, reactive oxygen species and mitochondrial Ca2+. Pdp1 overexpression significantly enhances the mitochondrial indices and pyruvate dehydrogenase activity and reduces the expression of cardiac differentiation marker mRNA and the cardiac differentiation rate. A knockdown of the Pdp1 gene promotes the expression of cardiac differentiation marker mRNA and the cardiac differentiation rate Mus musculus