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Literature summary for 3.1.3.43 extracted from

  • Shan, C.; Kang, H.B.; Elf, S.; Xie, J.; Gu, T.L.; Aguiar, M.; Lonning, S.; Hitosugi, T.; Chung, T.W.; Arellano, M.; Khoury, H.J.; Shin, D.M.; Khuri, F.R.; Boggon, T.J.; Fan, J.
    Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth (2014), J. Biol. Chem., 289, 21413-21422.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.43

Protein Variants

Protein Variants Comment Organism
Y94F phosphorylation-deficient mutant. Expression of the mutant in H-1299 cells leads to decreased proliferation under hypoxia and increased oxidative phosphorylation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O Homo sapiens
-
 [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Tyr-94 and Tyr-381phosphorylation through FGFR1 inhibit the enzyme activity by blocking lipoic acid binding Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
EoL-1 cell
-
 Homo sapiens
-
HEL cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
KG-1A cell
-
 Homo sapiens
-
MO-91 cell
-
 Homo sapiens
-
MOLM-14 cell
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O
-
 Homo sapiens [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDP1
-
 Homo sapiens
pyruvate dehydrogenase phosphatase 1
-
 Homo sapiens