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Literature summary for 3.1.3.43 extracted from

  • Hans, S.K.; Camara, F.; Altiti, A.; Martin-Montalvo, A.; Brautigan, D.L.; Heimark, D.; Larner, J.; Grindrod, S.; Brown, M.L.; Mootoo, D.R.
    Synthesis of C-glycoside analogues of beta-galactosamine-(1-4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha (2010), Bioorg. Med. Chem., 18, 1103-1110.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
(1S)-1,5-anhydro-1-{[(1R,2R,3R,4S,5S,6S)-2,3,4,5-tetrahydroxy-6-methoxycyclohexyl]methyl}-D-galactitol i.e. C-INS-2-OH the deaminated analogue of C-INS-2 Rattus norvegicus
(1S)-2-amino-1,5-anhydro-2-deoxy-1-{[(1R,2R,3R,4S,5S,6S)-2,3,4,5-tetrahydroxy-6-methoxycyclohexyl]methyl}-D-galactitol i.e. C-INS-2, the C-glycoside of INS-2 Rattus norvegicus
4-O-beta-D-galactosaminyl-3-O-methyl-D-chiro-inositol i.e. INS-2, allosteric activation, docking study using crystal structure of the enzyme PDHP1, PDB ID 2PNQ, and mechanism, overview Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Synonyms

Synonyms Comment Organism
PDHP
-
 Rattus norvegicus
pyruvate dehydrogenase phosphatase
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function allosteric activation of pyruvate dehydrogenase phosphatase and protein phosphatase 2Calpha leads to insulin-mimetic and insulin-sensitizing effects Rattus norvegicus