Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.43 extracted from

  • Korotchkina, L.G.; Sidhu, S.; Patel, M.S.
    R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase (2004), Free Radic. Res., 38, 1083-1092.
    View publication on PubMed
Search for more literature for 3.1.3.43

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(R)-dehydrolipoic acid 30% inhibition at 5 mM on phosphorylation at site 1 of E1, 20% inhibition at 5 mM on phosphorylation at site 2 of E1, 25% inhibition at 5 mM on phosphorylation at site 3 of E1 Rattus norvegicus
(R)-lipoic acid 30% inhibition at 5 mM on phosphorylation at site 1 of E1, 20% inhibition at 5 mM on phosphorylation at site 2 of E1, 25% inhibition at 5 mM on phosphorylation at site 3 of E1 Rattus norvegicus
(S)-lipoic acid 30% inhibition at 5 mM on phosphorylation at site 1 of E1, 20% inhibition at 5 mM on phosphorylation at site 2 of E1, 25% inhibition at 5 mM on phosphorylation at site 3 of E1 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O
-
 Rattus norvegicus [pyruvate dehydrogenase (lipoamide)] + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDP1
-
 Rattus norvegicus
PDP2
-
 Rattus norvegicus
pyruvate dehydrogenase phosphatase
-
 Rattus norvegicus