Literature summary for 3.1.3.43 extracted from

Roche, T.E.; Hiromasa, Y.; Turkan, A.; Gong, X.; Peng, T.; Yan, X.; Kasten, S.A.; Bao, H.; Dong, J.
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 (2003), Eur. J. Biochem., 270, 1050-1056.

Search for more literature for 3.1.3.43

Activating Compound

Activating Compound	Comment	Organism	Structure
Ca2+	stimulates PDP1 at micromolar concentrations	Mammalia
additional information	overview on interactions of Ca2+, Mg2+, spermine, and enzyme subunits	Mammalia
spermine	reduces Km-value for Mg2+	Mammalia

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required, Km-value of PDP1 is 2 mM in absence and 0.4 mM in presence of spermine, Km-value of PDP2 is 16 mM in absence and 3 mM in presence of spermine	Mammalia

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
52000	-	PDP1, 1 * 52000, catalytic subunit,+ 1 * 69000, regulatory subunit, overview	Mammalia
69000	-	PDP1, 1 * 52000, catalytic subunit,+ 1 * 69000, regulatory subunit, overview	Mammalia

Organism

Organism	UniProt	Comment	Textmining
Mammalia	-	two isoforms	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipose tissue	PDP2	Mammalia	-

Subunits

Subunits	Comment	Organism
heterodimer	PDP1, 1 * 52000, catalytic subunit,+ 1 * 69000, regulatory subunit, overview	Mammalia
More	overview on interactions and binding of subunits	Mammalia

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)