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Literature summary for 3.1.3.40 extracted from
- Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin-(streptidino)phosphate (1971), J. Biol. Chem., 246, 7034-7040.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cystamine | - |
Streptomyces galbus |  |
| cystamine | - |
Streptomyces griseocarneus | |
| cystamine | - |
Streptomyces griseus | |
| formamide disulfide hydrochloride | - |
Streptomyces galbus | |
| formamide disulfide hydrochloride | - |
Streptomyces griseocarneus | |
| formamide disulfide hydrochloride | - |
Streptomyces griseus | |
| p-hydroxymercuribenzoate | - |
Streptomyces galbus | |
| p-hydroxymercuribenzoate | - |
Streptomyces griseocarneus | |
| p-hydroxymercuribenzoate | - |
Streptomyces griseus | |
| PO43- | - |
Streptomyces galbus | |
| PO43- | - |
Streptomyces griseocarneus | |
| PO43- | - |
Streptomyces griseus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | absolute and relatively specific requirement for | Streptomyces griseus | |
| Mg2+ | absolute and relatively specific requirement for | Streptomyces griseocarneus | |
| Mg2+ | absolute and relatively specific requirement for | Streptomyces galbus | |
| additional information | Mn2+, Zn2+, Ca2+, Cu2+, Fe2+, K+ no substitute for Mg2+ | Streptomyces griseus | |
| additional information | Mn2+, Zn2+, Ca2+, Cu2+, Fe2+, K+ no substitute for Mg2+ | Streptomyces griseocarneus | |
| additional information | Mn2+, Zn2+, Ca2+, Cu2+, Fe2+, K+ no substitute for Mg2+ | Streptomyces galbus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | Streptomyces griseus | streptomycin biosynthesis | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | Streptomyces griseocarneus | streptomycin biosynthesis | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | Streptomyces galbus | streptomycin biosynthesis | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | Streptomyces griseus | streptidine biosynthesis | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | Streptomyces griseocarneus | streptidine biosynthesis | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | Streptomyces galbus | streptidine biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces galbus | - |
ATCC 14077 | - |
| Streptomyces griseocarneus | - |
ATCC 12628 | - |
| Streptomyces griseus | - |
ATCC 12475 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Streptomyces griseus | - |
| mycelium | - |
Streptomyces griseocarneus | - |
| mycelium | - |
Streptomyces galbus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | - |
Streptomyces griseus | 1-guanidino-1-deoxy-scyllo-inositol + phosphate | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | - |
Streptomyces griseocarneus | 1-guanidino-1-deoxy-scyllo-inositol + phosphate | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | - |
Streptomyces galbus | 1-guanidino-1-deoxy-scyllo-inositol + phosphate | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | streptomycin biosynthesis | Streptomyces griseus | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | streptomycin biosynthesis | Streptomyces griseocarneus | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | streptomycin biosynthesis | Streptomyces galbus | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | streptidine biosynthesis | Streptomyces griseus | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | streptidine biosynthesis | Streptomyces griseocarneus | ? | - |
? | |
| 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O | streptidine biosynthesis | Streptomyces galbus | ? | - |
? | |
| 2-guanidino-2-deoxy-neo-inositol 5-phosphate + H2O | - |
Streptomyces griseus | ? | - |
? | |
| 2-guanidino-2-deoxy-neo-inositol 5-phosphate + H2O | - |
Streptomyces griseocarneus | ? | - |
? | |
| 2-guanidino-2-deoxy-neo-inositol 5-phosphate + H2O | - |
Streptomyces galbus | ? | - |
? | |
| N-amidinostreptamine phosphate + H2O | - |
Streptomyces griseus | N-amidinostreptamine + phosphate | - |
? | |
| N-amidinostreptamine phosphate + H2O | - |
Streptomyces griseocarneus | N-amidinostreptamine + phosphate | - |
? | |
| N-amidinostreptamine phosphate + H2O | - |
Streptomyces galbus | N-amidinostreptamine + phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Streptomyces griseus |
| 7.4 | - |
- |
Streptomyces griseocarneus |
| 7.4 | - |
- |
Streptomyces galbus |
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