Any feedback?
Literature summary for 3.1.3.4 extracted from
- Lipid phosphate phosphatase 3 in vascular pathophysiology (2018), Atherosclerosis, 271, 156-165 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lysophosphatidic acid + H2O | Mus musculus | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | monoacylglycerol + phosphate | - |
? |  |
| lysophosphatidic acid + H2O | Homo sapiens | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | monoacylglycerol + phosphate | - |
? | |
| sphingosine-1-phosphate + H2O | Mus musculus | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | sphingosine + phosphate | - |
? | |
| sphingosine-1-phosphate + H2O | Homo sapiens | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | sphingosine + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O14495 | - |
- |
| Mus musculus | Q99JY8 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
| lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
| lysophosphatidic acid + H2O | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Mus musculus | monoacylglycerol + phosphate | - |
? | |
| lysophosphatidic acid + H2O | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Homo sapiens | monoacylglycerol + phosphate | - |
? | |
| sphingosine-1-phosphate + H2O | - |
Mus musculus | sphingosine + phosphate | - |
? | |
| sphingosine-1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? | |
| sphingosine-1-phosphate + H2O | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Mus musculus | sphingosine + phosphate | - |
? | |
| sphingosine-1-phosphate + H2O | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Homo sapiens | sphingosine + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipid phosphate phosphatase 3 | - |
Mus musculus |
| lipid phosphate phosphatase 3 | - |
Homo sapiens |
| LPP3 | - |
Mus musculus |
| LPP3 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | LPP3 deficiency, specifically targeted at vascular cell types, induces endothelial permeability, promotes leukocyte adhesion to endothelial cells and stimulates smooth muscle cell proliferation. Hepatocyte-specific Plpp3 deficiency, by modulating the plasma lipidome, exacerbates atherosclerosis development in Apoe-/-x01mice | Mus musculus |
| malfunction | LPP3 deficiency, specifically targeted at vascular cell types, induces endothelial permeability, promotes leukocyte adhesion to endothelial cells, and stimulates smooth muscle cell proliferation | Homo sapiens |
| physiological function | LPP3 activity is crucial for vascular and heart development | Mus musculus |
| physiological function | LPP3 activity is crucial for vascular and heart development | Homo sapiens |
| physiological function | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Mus musculus |
| physiological function | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
