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Literature summary for 3.1.3.4 extracted from

  • Chatterjee, I.; Humtsoe, J.O.; Kohler, E.E.; Sorio, C.; Wary, K.K.
    Lipid phosphate phosphatase-3 regulates tumor growth via beta-catenin and Cyclin-D1 signaling (2011), Mol. Cancer, 10, 51.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingosine 1-phosphate + H2O Homo sapiens
-
 sphingosine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
 Homo sapiens
-
SW-480 cell
-
 Homo sapiens
-
U-118MG cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingosine 1-phosphate + H2O
-
 Homo sapiens sphingosine + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 38000-40000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase-3
-
 Homo sapiens
LPP3
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction lipid phosphate phosphatase-3-knockdown inhibits both U-87 and U-118 glioblastoma cell proliferation in culture and tumor growth in xenograft assays. Lipid phosphate phosphatase-3-knockdown reduces beta-catenin, cyclin-D1, and CD133 expression, with a concomitant increase in phosphorylated beta-catenin Homo sapiens
physiological function forced expression of lipid phosphate phosphatase-3 in human colon tumor (SW-480) cells potentiates tumor growth via increased beta-catenin stability and cyclin-D1 synthesis. Elevated expression of lipid phosphate phosphatase-3 has no tumorigenic effects on primary cells. Lipid phosphate phosphatase-3 regulates glioblastoma cell migration Homo sapiens